Health

I would like to present some health problems that are common for the Chinese Crested dogs.  These problems are not specific to the breed itself and may be  quite common for other breeds also. The gene pool for the Chinese Crested is from a very limited stock (see breed history) and everybreeder should have at least the eyes and the patellars of their breeding dogs certified.

 

Standard health certificate for eyes examination (CERF or ECVO) should looks like one of these:

Certyficate  veronicacerf08.jpg (159991 bytes)

 

     
Ask the breeder to see the certification papers for these tests.
Genetic test certificate prcd-PRA should looks like these: certificate certificate        
Genetic test certificate PLL (Primary Lens Luxation) should looks like this:          

Chinese crested dog as it is a miniature breed can suffer from  diseases which are common for miniature breeds e.g.

  • Patella Luxation (PL)

  • Legg-Calve-Perthes (LCP)

Other diseases:

  • Keratoconjunctivitus Sicca (KCS) or Dry Eye

  • PRA (Progressive Retinal Atrophy) - several forms

  • Persistent Pupillary Membrane (PPM)

  • RPED

  • Lens Luxation (LL), Primary Lens Luxation (PLL)

  • Cataract

Diseases which are probably conected with hairlessness:

Genetic Research

LCPD Research /sadly chinese cresteds were excluded/

Dna Submission Form
Informed Consent Form
Blood Collection Instructions

  http://www.clemson.edu/cafls/departments/genbiochem/people/astarr.html

http://www.clemson.edu/cafls/departments/genbiochem/people/faculty_web/kmurphy/projects/lcpd.html

Our breed has a disease called Legg Calve Perthes Disease (LCPD). This disease is caused by the disruption of the blood supply to the head of the femur (the round bone which fits into the hip socket). When this happens, the result is death of bone cells and femur head gets deformed. There appears to be an increasing incidence of this disease showing up in Chinese Cresteds. This lead to contact with researcher Alison N. Starr, Ph.D, Assistant Research Professor on Canine Genetics Laboratory at Clemson University.

They are very interested in including the Chinese Crested in the study and this is a big oppertunity for us to identify the mutation causing LCPD and we could have a genetic test in the future (like we have with prcd-PRA).To accomplish this we need your help!!! The minimum blood samples required is 25 affected and 25 unaffected but the more samples they get over all increases the odds of them identifying the gene/s involved in this disease.

 

PRA Research (non-prcd) and retinophaty

 

- OptiGen®, LLC (USA)
Cornell Business & Technology Park · 767 Warren Road, Suite 300
Ithaca, New York 14850
Tel: 607 257 0301 · Fax: 607 257 0353
email: genetest@optigen.com

 http://www.vrcc.com/ophthamology/docs/OcularDisordersCanine2007.pdf

pages: 24-30

"1. Dr Simon Petersen-Jones:
...
b. PRA
We are researching and actively seeking DNA samples and information from any breed with a PRA problem for which the gene mutation has not been identified, including the following breeds: (funded by the AKC-Canine Health Foundation and associated breed clubs)
Belgian Tervurens
Chinese Crested (non-prcd PRA)
Collies
Irish Wolfhounds
Italian Greyhounds
Miniature longhaired dachshunds
Old English Sheepdogs
Papillons
Tibetan Terriers
..."

- Dr. Simon Petersen-Jones
Associate Professor, Comparative Ophthalmology,
Department of Small Animal Clinical Sciences,
Michigan State University
D-208 Veterinary Medical Center
East Lansing. MI 48824-1314
Office Phone: 517-353-3278
Lab 1 Phone: 517-432-0144
Lab 2 Phone: 517-432-0010
Fax: 517-355-5164
Email: peter315@cvm.msu.edu

 

Short Information in regards to Chinese Crested Dog PRA Research

 

By  Dr. Kristina Narfström                                                                    January 10, 2010

Since approximately 1.5 years I’ve been engaged in PRA research concerning the Chinese Crested Dog (CCD). The background is that many cases of retinal blinding disease have been observed in CCDs in Sweden. Some of the affected dogs have been blood tested in regards to the prcd mutation, responsible for PRA in a number of dog breeds, and has also been found in CCDs affected by retinal blinding disease (see http://www.optigen.com). We have found that many of the cases observed in Sweden have been negative for this mutation even though they have gone blind with a retinal disease process.

Through examination of a large number of CCDs in Sweden and smaller groups of CCDs in USA, I have found that we are dealing with more than one problem in the breed in regards to retinal disease. First of all, there are a lot of color variations in the breed and this affects also the retinal appearance, causing color changes that may be difficult to differentiate from early stage PRA. Secondly, there appears to be a “new” type of retinal disease in the breed different from classical PRA. The disease is very slowly progressive and some cases lead to severe visual impairment or blindness.   The disorder appears to affect the outermost layer of the retina, not only photoreceptors primarily as in classical PRA.  Upon eye examination using indirect ophthalmoscopy, the disease has a somewhat different appearance than PRA of the prcd type. I call this “new” type of retinal problem CCD retinopathy. Thirdly, we also see classical PRA in the breed, in dogs that are positive for the prcd mutation.

Through research into the retinal problems of CCDs we will evaluate and study cases that have been diagnosed with PRA or PRA-like disease but that have been blood tested and are negative for the prcd mutation. In collaboration with the crestednetwork.se and the CCD breed club in Sweden, Dr. Tomas Bergstrom and Dr. Leif Andersson, both at the Swedish University of Agricultural Sciences and Uppsala University, and Dr. Gary Johnson and Liz Hansen, both at the University of Missouri, MO, USA, we want to find the gene/mutation for the CCD retinopathy. At the same time the plan is to characterize the disease clinically and using laboratory methods, such as electroretinography (ERG) and morphology (microscopic examination of tissues from affected individuals).

In order for us to succeed we would like to obtain blood samples from CCDs that have been diagnosed with retinal blinding disease/PRA but that have been blood tested and are negative for the prcd mutation. For this, fresh blood can be submitted in purple top vials (EDTA), together with a copy of the latest eye examination certificate issued by a board certified veterinary ophthalmologist, and a copy of the pedigree of the affected dog. Initially we will screen for mutations known to cause PRA in other dog breeds, such as the CORD1 mutation. Then, further molecular genetic research will be performed.

Address for submission of blood in USA:

Animal Molecular Genetics Laboratory, Attention: Liz Hansen

University of Missouri –College of Veterinary Medicine

321 Connaway Hall

Columbia, MO 65211

 

Phone: 573 884 3712

e-mail: HansenL@missouri.edu

 

Thank you for your help!

 

KRISTINA NARFSTRÖM, DVM, PhD, DipECVO

Professor of Ophthalmology

University of Missouri-Columbia

www.vmth.missouri.edu/lco

 

 
EP - Epilepsy in Chinese Crested Dogs

Paw Print Genetics (USA)

Epilepsy project at Paw Print Genetics. (update 02.2016)

We have received samples for 201 dogs and extracted DNA on all of those.
A subset of these dogs, the affected dogs and matched normal controls, were used for a genome wide association studies (GWAS). The GWAS analysis revealed a few locations in the genome to search for candidate genes and mutations. To narrow these regions, we need to do linkage analysis, which requires the affected dogs and both parents. We are near the end of doing a pedigree analysis for the samples that we have to match affected dogs and parents and see what samples we are missing. We will then try to collect the missing samples by contacting the owner/breeder. The trios (mom, dad and affected pup, and in some cases extended families) DNAs will be used for linkage analysis to try to narrow the regions in the genome. Candidate genes will be identified and sequenced for mutations. Once a mutation has been identified, we will develop a diagnostic test to screen all samples that we have collected.

 
Bern University (Switzerland)
Epilepsy can occur in humans and in many dog breeds. Epilepsy can result from brain damage (e.g. trauma), or genetic mutations. In dogs the hereditary forms of epilepsy are probably very important. We plan to investigate the underlying genetic mechanisms for various forms of epilepsy in different dog breeds. The goal of our research is the development of diagnostic tests, which will allow a reduction of the epilepsy cases by a targeted breeding strategy. For our research we need blood samples from epilepsy affected dogs and their relatives.
 

Genetic Tests for chinese crested dogs:

prcd-PRA

rcd3 PRA

PLL

DM

vWD II

CMSD

 
 DNA LABORATORIES FOR TESTING YOUR CHINESE CRESTED
 
Other DNA testing labs: http://www.offa.org/dna_labs.html
 
Links:
Chinese Crested Health Database http://www.crestedhealth.net/
European Crested DiVision http://ecd.fullmonty.nl/ 
Chinese Crested Links - Health http://crestedlinks.2n3055.com/htm/health.html 
Chinese Crested Health UK http://liddyleaze.netfirms.com/alldogs.htm 
UK Chinese Crested Health http://www.geocities.com/oolagha/crestedhealthUK.html 
ACCC Health Survey (.pdf) http://accc.chinesecrestedclub.info/forms/health_survey.pdf 
ACCC Health Survey (.doc) http://accc.chinesecrestedclub.info/forms/health_survey.doc 
OFA Chinese Crested Health Survey http://www.offa.org/surveys/survey_crested.html
Orthopedic Foundation for Animals   http://www2.offa.org/index.html, http://www.offa.org/
Veterinary Medical Database http://www.vmdb.org/ 
Polish Small Animal Veterinary Association (PSAVA) http://www.pslwmz.org.pl/ 
Patella Luxation http://www2.offa.org/index.html 
http://www.crestars.com/patellas.htm 
http://www.bhejei.com/health-patella.htm 
http://www.fullmonty.nl/info/patellaluxation.html 
http://www.chinesecrested.no/article/health/Patellar+Luxation 
http://www.timegarden.nl/Patellar_Luxation.htm 
Legg-Calve-Perthes http://www2.offa.org/index.html 
http://www.vetinfo.com/dencyclopedia/deleggcp.html 
http://www.fullmonty.nl/info/lcp.html 
http://www.chinesecrested.no/article/health/Legg-Calve-Perthes+%28LCP%29 
EyeVet http://www.eyevet.info/index.html 
CERF (Canine Eye Registration Fundation) http://www.vgl.ucdavis.edu/research/canine/ 
PRA http://www.sheepdog.com/diseases/pra/back.html
http://www.sheepdog.com/diseases/pra/pramenu.html 
http://www.fullmonty.nl/info/pra.html 
http://www.chinesecrested.no/article/health/Progressive+Retinal+Atrophi+%28PRA%29+ 
http://www.timegarden.nl/PRA_gb.htm 
Glaucoma http://www.fullmonty.nl/info/glaucoma.html 
Lens Luxation http://www.fullmonty.nl/info/lensluxation.html 
Cataract http://www.fullmonty.nl/info/cataract.html 
Keratoconjunctivitus Sicca (KCS)/ Dry Eye http://www.chinesecrested.no/article/health/Keratoconjunctivitus+Sicca+%28KCS%29+or+Dry+Eye 
http://www.geocities.com/Heartland/2169/taffy.html 
http://www.geocities.com/Heartland/2169/parotid.html
Genetic test for prcd-PRA http://www.optigen.com 
Canine Genome Project http://www.vgl.ucdavis.edu/research/canine/ 
Canine Genetic Diseases Network http://www.caninegeneticdiseases.net/ 
Laboklin - genetic tests (Germany) http://www.laboklin.de 
Closed Ear Canal = CEC http://www.geocities.com/Heartland/2169/closedears.html 
http://www.huacaviringo.com/artikelen/CEC/
Deafness http://www.lsu.edu/deafness/genetics.htm 
http://www.lsu.edu/deafness/deaf.htm 
http://www.thedca.org/hearing.html 
http://www.lancedal.demon.co.uk/health/baer-hearing-test.htm 
BEAR Test http://www.geocities.com/Heartland/2169/baer.html 
http://www.lsu.edu/deafness/baerexpl.htm 
http://www.lsu.edu/deafness/baersite.htm 
PNA - Progressive Neuronal Abiotrophy = CMSD - Canine Multiple System Degeneration http://www.angelfire.com/ia2/kerryblues/pna.html
http://www.uskbtc.com/article.php/226 
http://www.uskbtc.com/article.php/333 
  http://jhered.oxfordjournals.org/cgi/content/full/96/7/727
Dental Information http://www.dentalvet.com/Encyclopedia/P00352_SC01108.htm 
V.E.I.N http://vein.library.usyd.edu.au/links/dogs.html 
Canine Inherited Disorders Database Canine Inherited Disorders Database
AKC Canine Health Foundation http://www.akcchf.org/ 
VeterinianPartner http://www.veterinarypartner.com/ 
Pet Pharm http://www.petpharm.org/ 
European College of Veterinary Ophthalmologists http://www.ecvo.org/public/index.htm

 

Webmaster

 

Home Copyright © 2004- Katarzyna Zienkiewicz - Rosa Thea Kennel